Germ Cell Tumors: Updates on Epidemiology, Biology, and Treatment Considerations
نویسندگان
چکیده
منابع مشابه
Genetics and biology of adult human male germ cell tumors.
Adult human male germ cell tumors (GCTs) provide a unique opportunity to study the generation of a transformed pluripotential cell from a totipotential GC in lineage differentiation and on the path to gametogenesis. The pluripotentiality of the tumor cells manifests as histological differentiation into GC-like undifferentiated (SE), primitive zygotic (EC), embryonal-like somatically differentia...
متن کاملBiology and Molecular Markers of Malignant Gonadal Germ Cell Tumors
5 Original Publications 8 Abbreviations 9 Introduction 10 Review of the Literature 11 1. Germ cells 11 1.1 Inner cell mass and embryonic stem cells 11 1.2 Factors essential for maintenance of pluripotency and self-renewal 11 1.3 Development and migration of germ cells 14 2. Gonadal development 16 2.1 Ovarian differ entiation 17 2.2 Testicular differentiation 18 3. GATA transcription factors in ...
متن کاملTreatment of germ cell tumors--update 2006.
Testicular cancer is considered a malignancy with a high cure rate even in patients with metastatic disease. Treatment strategies are based on the extent of the disease and prognostic factors and require cooperation of medical specialists such as medical oncologists, radiation oncologists and urologic surgeons. Today, cure rates of 95–99% for patients with early stage testicular cancer and 50–9...
متن کاملNeuroendocrine tumors: treatment updates.
Neuroendocrine tumors of the gastroenteropancreatic tract remain a difficult array of neoplasia to treat. Treatment of advanced and metastatic gastroenteropancreatic neuroendocrine tumors has traditionally been difficult with few systemic treatment options. In 2011, two new targeted therapies, everolimus and sunitinib were approved for treatment of pancreatic neuroendocrine tumor. The approval ...
متن کاملThe Epidemiology of Malignant Germ Cell Tumors: The EUROCARE Study
Germ cell tumors (GCTs) comprise a heterogeneous group of tumors in terms of histology, age at diagnosis, anatomical site and prognosis. Here we describe the epidemiology of GCT on the basis of data from European population-based cancer registries (CRs) analysed in the framework of the EUROCARE (European Cancer Registrybased study on survival and care of cancer patients) project, which has moni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advances in Urology
سال: 2018
ISSN: 1687-6369,1687-6377
DOI: 10.1155/2018/4821084